Mitochondrial fusion

Across TCGA patient cohorts, RNA activity of the Mitochondrial fusion pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EEF2, RPS5, and GTF2F1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial fusion activity versus EEF2 in OV (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EEF2 →	-0.204	-0.031	.003	<.001	3	6
GBM	RPS5 →	-0.196	-0.038	<.001	<.001	3	6
CCRCC	GTF2F1 →	-0.118	-0.031	.001	<.001	3	5
GBM	RPS13 →	-0.242	-0.032	<.001	<.001	3	5
GBM	RPS16 →	-0.236	-0.039	.003	<.001	3	5
HNSC	ZNF638_S650 →	+0.647	+0.058	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008053 vs EEF2 — OV

Explore this scatter interactively →