Mitochondrial fusion

Across TCGA cell cohorts, RNA activity of the Mitochondrial fusion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDK, PRDM11, and GRHPR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MDK grouped by Mitochondrial fusion-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MDK →	-4.224	-1.094	<.001	<.001	3	5
SKIN	PRDM11 →	-0.545	-0.736	.008	.009	3	5
OVARY	GRHPR →	+0.490	+0.890	.003	.002	3	4
BLOOD_Leukemia	LIN7B →	+0.782	+1.058	<.001	.004	3	4
BLOOD_Leukemia	CARD14 →	+0.238	+1.235	.002	.003	3	4
KIDNEY	TJP3 →	+0.891	+1.361	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MDK by Mitochondrial fusion activity — BREAST

Explore this box plot interactively →