Motor neuron axon guidance

Across TCGA patient cohorts, RNA activity of the Motor neuron axon guidance pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DENND2D, C1R, and CALU_S69, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Motor neuron axon guidance activity versus DENND2D in PDAC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	DENND2D →	-0.262	-0.039	.002	.002	3	6
LSCC	C1R →	+0.559	+0.081	<.001	<.001	3	5
LUAD	CALU_S69 →	+0.951	+0.061	<.001	<.001	3	5
LSCC	CDKN2AIP →	-0.171	-0.062	.003	<.001	3	5
LSCC	POFUT1 →	+0.259	+0.067	<.001	<.001	3	5
OV	COA4 →	-0.613	-0.035	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008045 vs DENND2D — PDAC

Explore this scatter interactively →