Motor neuron axon guidance

Across TCGA cell cohorts, RNA activity of the Motor neuron axon guidance pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC3, MYCBP2, and PLXNA4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAC3 grouped by Motor neuron axon guidance-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RAC3 →	-0.362	-1.695	.001	<.001	3	5
LUNG_NSCLC_LUAD	MYCBP2 →	-0.095	-0.494	.006	.001	3	5
BLOOD_Myeloma	PLXNA4 →	-0.597	-2.052	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CD2 →	-0.256	-0.241	.002	.009	3	4
BLOOD_Leukemia	CAT →	-0.104	-0.888	.007	.003	3	3
BLOOD_Myeloma	FGF10 →	-0.343	-1.413	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAC3 by Motor neuron axon guidance activity — BLOOD_Myeloma

Explore this box plot interactively →