Motor neuron axon guidance

Across TCGA cell cohorts, RNA activity of the Motor neuron axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VEPH1, NBDY, and BDH2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VEPH1 grouped by Motor neuron axon guidance-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	VEPH1 →	+2.177	+0.761	<.001	.007	3	4
OESOPHAGUS	NBDY →	+1.364	+0.412	.008	.005	3	4
LUNG_SCLC	BDH2 →	-1.636	-1.188	<.001	.007	3	4
LIVER	ANKRD2 →	+2.274	+1.501	.009	.003	3	4
OVARY	LMBR1L →	-0.760	-0.450	<.001	.007	3	4
LARGE_INTESTINE	ARHGAP23 →	+1.896	+0.325	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VEPH1 by Motor neuron axon guidance activity — KIDNEY

Explore this box plot interactively →