Motor neuron axon guidance

Across TCGA cell cohorts, RNA activity of the Motor neuron axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRP1, PLXNA3, and NRP2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Motor neuron axon guidance activity versus NRP1 in SKIN (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NRP1 →	+2.156	+0.081	<.001	<.001	3	9
LIVER	PLXNA3 →	+1.743	+0.212	<.001	.003	3	9
LUNG_NSCLC_LUAD	NRP2 →	+2.204	+0.141	<.001	<.001	3	7
PANCREAS	MRPL46 →	-0.581	-0.125	.001	.002	3	6
SKIN	PLCG2 →	-0.722	-0.094	<.001	<.001	3	6
BREAST	CACNB3 →	+1.277	+0.152	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008045 vs NRP1 — SKIN

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