Neuron recognition

Across TCGA patient cohorts, RNA activity of the Neuron recognition pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX7A1, ZCCHC24, and MYLK, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron recognition activity versus COX7A1 in HNSC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	COX7A1 →	+1.635	+1.267	<.001	<.001	3	9
OV	ZCCHC24 →	+1.128	+0.761	<.001	<.001	3	9
BRCA	MYLK →	+1.153	+0.628	<.001	<.001	3	9
BRCA	NAP1L3 →	+0.823	+0.690	<.001	<.001	3	9
OV	COMP →	+2.272	+0.718	<.001	<.001	3	8
BRCA	MRC2 →	+1.144	+0.746	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008038 vs COX7A1 — HNSC

Explore this scatter interactively →