Neuron recognition

Across TCGA cell cohorts, RNA activity of the Neuron recognition pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AP2M1, SLC25A24, and SOCS5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron recognition activity versus AP2M1 in LIVER (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	AP2M1 →	+0.676	+0.212	.003	.001	3	6
LIVER	SLC25A24 →	+3.397	+0.215	.001	.002	3	5
LIVER	SOCS5 →	+1.021	+0.195	.006	<.001	3	4
LUNG_NSCLC_LUAD	TRIM24 →	-0.683	-0.113	<.001	<.001	3	4
BLOOD_Leukemia	VASH1 →	-1.621	-0.183	.003	.002	3	4
OVARY	C11orf68 →	+0.873	+0.140	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008038 vs AP2M1 — LIVER

Explore this scatter interactively →