Cell recognition

Across TCGA patient cohorts, RNA activity of the Cell recognition pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, SF3B1, and STAB1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell recognition activity versus RCSD1 in OV (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RCSD1 →	+0.643	+0.029	<.001	<.001	3	9
LSCC	SF3B1 →	-0.237	-0.050	<.001	<.001	3	9
GBM	STAB1 →	+0.419	+0.049	.002	<.001	3	9
LSCC	UTP14A →	-0.349	-0.051	<.001	<.001	3	9
BRCA	WDR36 →	-0.331	-0.020	<.001	<.001	3	9
OV	WIPF1 →	+0.517	+0.026	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008037 vs RCSD1 — OV

Explore this scatter interactively →