Cell recognition

Across TCGA patient cohorts, RNA activity of the Cell recognition pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEDAG, CCN4, and CXCL12, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell recognition activity versus MEDAG in OV (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MEDAG →	+1.712	+0.237	<.001	<.001	3	9
BRCA	CCN4 →	+1.107	+0.205	<.001	<.001	3	9
OV	CXCL12 →	+1.541	+0.243	.002	<.001	3	9
OV	SPARC →	+1.529	+0.245	<.001	<.001	3	9
CCRCC	DCN →	+1.867	+0.158	<.001	.004	3	9
COAD	PRRX1 →	+1.252	+0.137	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008037 vs MEDAG — OV

Explore this scatter interactively →