Cell recognition

Across TCGA cell cohorts, RNA activity of the Cell recognition pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BECN1, CENPM, and ZNF219, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BECN1 grouped by Cell recognition-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	BECN1 →	-0.648	-1.458	.004	<.001	3	5
STOMACH	CENPM →	+0.816	+0.897	<.001	.005	3	4
SOFT_TISSUE	ZNF219 →	-1.901	-1.272	.001	.002	3	4
SKIN	ZMAT3 →	-1.532	-1.022	<.001	.001	3	4
SKIN	TBC1D9 →	-0.612	-0.987	.005	<.001	3	4
SKIN	SPATA13 →	-1.222	-1.034	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BECN1 by Cell recognition activity — STOMACH

Explore this box plot interactively →