Cell recognition

Across TCGA cell cohorts, RNA activity of the Cell recognition pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMP3, ACO1, and ABL2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell recognition activity versus EMP3 in LUNG_NSCLC_LUSC (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	EMP3 →	+4.484	+0.172	.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	ACO1 →	+1.404	+0.201	.005	.003	3	7
BREAST	ABL2 →	+1.509	+0.180	<.001	.001	3	7
LUNG_NSCLC_LUSC	MYBL1 →	+2.056	+0.197	<.001	<.001	3	7
BREAST	LGALS1 →	+3.607	+0.272	.001	<.001	3	6
LUNG_NSCLC_LUSC	CEP85L →	+0.647	+0.172	.005	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008037 vs EMP3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →