tRNA processing

Across TCGA patient cohorts, RNA activity of the tRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GATAD2B, AHNAK_S5593, and CD2AP_S510, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA processing activity versus GATAD2B in LSCC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GATAD2B →	+0.267	+0.032	<.001	<.001	3	6
GBM	AHNAK_S5593 →	-0.729	-0.031	<.001	.001	3	6
GBM	CD2AP_S510 →	-0.397	-0.025	<.001	<.001	3	5
LSCC	RCOR3 →	+0.395	+0.049	<.001	<.001	3	5
LSCC	RPRD2 →	+0.271	+0.028	<.001	<.001	3	5
LSCC	SFPQ →	+0.167	+0.024	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008033 vs GATAD2B — LSCC

Explore this scatter interactively →