tRNA processing

Across TCGA cell cohorts, RNA activity of the tRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIRAP, FLAD1, and PMVK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TIRAP grouped by tRNA processing-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TIRAP →	-0.518	-0.198	.001	<.001	3	4
LARGE_INTESTINE	FLAD1 →	-0.352	-0.172	.008	<.001	3	4
LARGE_INTESTINE	PMVK →	-0.652	-0.190	.004	.003	3	4
BONE	PTTG1 →	+1.585	+0.271	<.001	<.001	3	4
LARGE_INTESTINE	LRRC66 →	-0.726	-0.202	.001	.002	3	4
LUNG_SCLC	TTC21A →	-1.351	-0.166	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TIRAP by tRNA processing activity — LARGE_INTESTINE

Explore this box plot interactively →