tRNA processing

Across TCGA cell cohorts, RNA activity of the tRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are QSOX1, CCN1, and ANXA8L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA processing activity versus QSOX1 in OVARY (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	QSOX1 →	-1.652	-1.040	.002	<.001	3	5
LUNG_NSCLC_LUAD	CCN1 →	-2.109	-0.599	.006	.001	2	5
LUNG_NSCLC_LUAD	ANXA8L1 →	-2.496	-0.694	.004	.001	2	5
LARGE_INTESTINE	S100A11 →	-1.664	-0.711	<.001	.005	3	4
LARGE_INTESTINE	MRPL42 →	+0.694	+0.463	<.001	.002	3	4
OVARY	SAFB2 →	+0.863	+0.706	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008033 vs QSOX1 — OVARY

Explore this scatter interactively →