Regulation of heart contraction

Across TCGA patient cohorts, RNA activity of the Regulation of heart contraction pathway is significantly associated with the RNA expression of multiple genes, with the KIRC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC70, PEAK1, and TEK, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart contraction activity versus LRRC70 in KIRC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	LRRC70 →	+0.784	+0.029	<.001	<.001	3	29
THYM	PEAK1 →	+1.118	+0.023	<.001	<.001	3	28
MESO	TEK →	+1.239	+0.016	<.001	<.001	3	28
MESO	GUCY1A2 →	+0.847	+0.018	<.001	<.001	3	28
SARC	MSRB3 →	+1.698	+0.026	<.001	<.001	3	28
SARC	MYLK →	+3.675	+0.027	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008016 vs LRRC70 — KIRC

Explore this scatter interactively →