Regulation of heart contraction

Across TCGA patient cohorts, RNA activity of the Regulation of heart contraction pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPM1, EFEMP1, and LMOD1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart contraction activity versus TPM1 in UCEC (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TPM1 →	+0.777	+0.048	<.001	<.001	3	10
OV	EFEMP1 →	+0.863	+0.032	<.001	<.001	3	10
UCEC	LMOD1 →	+1.188	+0.041	<.001	<.001	3	10
BRCA	LUM →	+0.996	+0.024	<.001	<.001	3	10
CCRCC	PDLIM5 →	+0.771	+0.027	<.001	<.001	3	10
UCEC	MSRB3 →	+1.029	+0.049	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008016 vs TPM1 — UCEC

Explore this scatter interactively →