Regulation of heart contraction

Across TCGA patient cohorts, RNA activity of the Regulation of heart contraction pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRPX, ITGA11, and TGFB1I1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart contraction activity versus SRPX in BRCA (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SRPX →	+1.054	+0.476	.001	.003	3	2
BRCA	ITGA11 →	+1.373	+0.483	<.001	.003	3	2
BRCA	TGFB1I1 →	+0.524	+0.243	.008	.006	3	2
BRCA	DPT →	+0.997	+0.315	<.001	.006	3	2
BRCA	SGMS2 →	+0.740	+0.374	.001	.003	3	2
BRCA	ACTA2-AS1 →	+1.114	+0.330	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008016 vs SRPX — BRCA

Explore this scatter interactively →