Regulation of heart contraction

Across TCGA cell cohorts, RNA activity of the Regulation of heart contraction pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPA1, GINS4, and IER2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPA1 grouped by Regulation of heart contraction-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RPA1 →	+0.879	+0.677	<.001	.002	3	5
LARGE_INTESTINE	GINS4 →	+0.800	+0.513	.001	.006	3	5
BREAST	IER2 →	-1.001	-0.349	<.001	.008	3	4
SKIN	CHD3 →	+0.670	+0.673	.003	.007	3	4
URINARY_TRACT	MUC12 →	-1.779	-1.673	.008	<.001	3	4
LARGE_INTESTINE	HELLS →	+0.802	+0.672	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPA1 by Regulation of heart contraction activity — LARGE_INTESTINE

Explore this box plot interactively →