Regulation of heart contraction

Across TCGA cell cohorts, RNA activity of the Regulation of heart contraction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCCB, IFIT3, and NMI, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart contraction activity versus PCCB in LUNG_SCLC (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PCCB →	-1.188	-0.311	<.001	<.001	3	5
LUNG_SCLC	IFIT3 →	+2.001	+0.256	<.001	<.001	3	5
LUNG_SCLC	NMI →	+2.354	+0.279	<.001	<.001	3	5
LUNG_SCLC	COX11 →	-0.551	-0.220	.008	.003	3	5
BREAST	MAPT →	-1.658	-0.170	.001	<.001	3	5
URINARY_TRACT	C1orf116 →	+3.290	+0.426	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008016 vs PCCB — LUNG_SCLC

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