Mechanosensory behavior

Across TCGA patient cohorts, RNA activity of the Mechanosensory behavior pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD276, CRTAP, and FARP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mechanosensory behavior activity versus CD276 in PDAC (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CD276 →	+0.369	+0.099	<.001	<.001	3	6
PDAC	CRTAP →	+0.414	+0.091	<.001	<.001	3	6
GBM	FARP1 →	+0.312	+0.107	<.001	<.001	3	6
BRCA	HTRA1 →	+0.940	+0.053	<.001	<.001	3	6
BRCA	ITGB5 →	+0.671	+0.056	<.001	<.001	3	6
LSCC	KARS1 →	-0.138	-0.046	.003	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007638 vs CD276 — PDAC

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