Mechanosensory behavior

Across TCGA cell cohorts, RNA activity of the Mechanosensory behavior pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZUP1, ANKRD18A, and MAPRE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZUP1 grouped by Mechanosensory behavior-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZUP1 →	+0.845	+0.900	.002	.005	3	4
BLOOD_Myeloma	ANKRD18A →	+2.389	+1.575	<.001	.002	3	4
SKIN	MAPRE1 →	-0.500	-1.166	.001	<.001	3	4
LUNG_NSCLC_LUSC	GPX3 →	-2.921	-1.218	.006	.003	3	3
LUNG_NSCLC_LUSC	CPS1 →	-2.528	-1.242	.009	.002	3	3
LARGE_INTESTINE	ZMYND8 →	-0.895	-0.715	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZUP1 by Mechanosensory behavior activity — LARGE_INTESTINE

Explore this box plot interactively →