Visual behavior

Across TCGA cell cohorts, RNA activity of the Visual behavior pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDSUB1, RGL4, and ZNF81, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDSUB1 grouped by Visual behavior-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	WDSUB1 →	-0.875	-0.892	.003	.005	3	4
LUNG_SCLC	RGL4 →	+0.322	+0.604	<.001	<.001	3	3
URINARY_TRACT	ZNF81 →	+1.153	+1.997	.004	<.001	3	3
LUNG_NSCLC_LUAD	GPR146 →	-0.690	-0.580	.002	.004	3	3
LUNG_SCLC	RIPK2 →	-1.802	-0.428	.003	.004	3	3
LUNG_SCLC	CAT →	-1.331	-0.425	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDSUB1 by Visual behavior activity — PANCREAS

Explore this box plot interactively →