Visual behavior

Across TCGA cell cohorts, RNA activity of the Visual behavior pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPHP1, GLYR1, and ISL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NPHP1 grouped by Visual behavior-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NPHP1 →	+0.220	+0.209	.002	.002	3	3
LARGE_INTESTINE	GLYR1 →	-0.189	-0.776	.009	.007	3	3
LUNG_NSCLC_LUAD	ISL2 →	+0.114	+0.772	.001	.001	3	3
BREAST	GPR26 →	+0.142	+0.548	.008	.004	3	3
BREAST	DIS3 →	-0.133	-0.726	.003	.002	3	3
BLOOD_Lymphoma	STYXL2 →	+0.515	+2.449	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NPHP1 by Visual behavior activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →