Feeding behavior

Across TCGA patient cohorts, RNA activity of the Feeding behavior pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP1_S592, DOCK10, and GSK3A_S21, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Feeding behavior activity versus AKAP1_S592 in OV (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AKAP1_S592 →	+0.730	+0.029	<.001	<.001	3	5
BRCA	DOCK10 →	-0.247	-0.021	.001	.007	3	5
LSCC	GSK3A_S21 →	-0.484	-0.026	.004	.003	3	5
PDAC	AKAP13_S2567 →	+0.284	+0.035	.006	.002	3	5
UCEC	SH3KBP1_S587 →	-0.345	-0.028	<.001	.005	3	4
UCEC	BCL2L1 →	-0.212	-0.032	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007631 vs AKAP1_S592 — OV

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