Feeding behavior

Across TCGA cell cohorts, RNA activity of the Feeding behavior pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R3F, CDNF, and NTN5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R3F grouped by Feeding behavior-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PPP1R3F →	-1.404	-1.464	<.001	.002	3	4
LIVER	CDNF →	-0.719	-1.178	.007	.004	3	4
LUNG_NSCLC_LUAD	NTN5 →	-0.471	-0.678	.005	.009	3	3
LUNG_NSCLC_LUAD	PRMT6 →	+1.189	+0.797	.008	<.001	2	4
LUNG_SCLC	THEMIS2 →	-1.573	-1.480	.003	<.001	3	3
LUNG_SCLC	FAR2 →	+3.120	+1.291	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R3F by Feeding behavior activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →