Feeding behavior

Across TCGA cell cohorts, RNA activity of the Feeding behavior pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDF15, SOGA1, and EME1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Feeding behavior activity versus GDF15 in SKIN (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GDF15 →	+4.168	+0.154	<.001	<.001	3	10
STOMACH	SOGA1 →	-1.989	-0.174	<.001	<.001	3	9
BLOOD_Leukemia	EME1 →	-0.912	-0.080	<.001	.004	3	8
STOMACH	FAM171A2 →	-1.067	-0.123	.002	.008	3	8
STOMACH	TUBA1A →	-2.849	-0.173	<.001	<.001	3	8
STOMACH	CRMP1 →	-1.860	-0.178	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007631 vs GDF15 — SKIN

Explore this scatter interactively →