Circadian rhythm

Across TCGA patient cohorts, RNA activity of the Circadian rhythm pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CARD9_S460, TNFAIP8, and BIN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Circadian rhythm activity versus CARD9_S460 in OV (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CARD9_S460 →	-0.817	-0.040	.003	<.001	3	6
LSCC	TNFAIP8 →	-0.352	-0.022	<.001	.001	3	5
LSCC	BIN2 →	-0.522	-0.027	<.001	.001	3	5
GBM	RPL23A →	-0.253	-0.027	<.001	<.001	3	5
LSCC	WIPF1 →	-0.256	-0.022	.005	.006	3	5
GBM	ARHGAP25 →	-0.385	-0.022	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007623 vs CARD9_S460 — OV

Explore this scatter interactively →