Circadian rhythm

Across TCGA patient cohorts, RNA activity of the Circadian rhythm pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGCA, OPRM1, and GDF5, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Circadian rhythm activity versus SGCA in COAD (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SGCA →	-1.107	-1.842	.004	.003	3	1
COAD	OPRM1 →	-0.019	-2.235	.005	<.001	3	1
COAD	GDF5 →	-0.350	-2.233	.004	<.001	3	1
COAD	FOXA1 →	+1.825	+1.831	<.001	.003	3	1
COAD	DNASE2B →	-0.442	-2.202	.001	<.001	3	1
COAD	IZUMO2 →	-1.117	-1.411	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007623 vs SGCA — COAD

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