Circadian rhythm

Across TCGA cell cohorts, RNA activity of the Circadian rhythm pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTSS2, ZMYM6, and FAM83G, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTSS2 grouped by Circadian rhythm-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MTSS2 →	+1.196	+0.108	.002	.007	3	5
LUNG_NSCLC_LUSC	ZMYM6 →	+0.661	+0.166	.007	.006	2	6
SKIN	FAM83G →	+1.254	+0.166	.003	.001	3	5
SOFT_TISSUE	MCU →	+1.041	+0.319	<.001	<.001	3	4
SOFT_TISSUE	RXRA →	+1.131	+0.204	.007	.004	3	4
BLOOD_Myeloma	SLC25A53 →	+0.826	+0.193	.002	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTSS2 by Circadian rhythm activity — BREAST

Explore this box plot interactively →