Circadian rhythm

Across TCGA cell cohorts, RNA activity of the Circadian rhythm pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOSC9, CNOT9, and RPL11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Circadian rhythm activity versus EXOSC9 in STOMACH (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EXOSC9 →	-0.641	-0.152	.007	.005	3	5
STOMACH	CNOT9 →	-0.792	-0.171	.005	.002	3	5
LUNG_SCLC	RPL11 →	+0.836	+0.179	<.001	.001	3	5
LUNG_NSCLC_LUAD	FOSL1 →	+1.668	+0.120	.002	.004	3	5
BREAST	TWF2 →	+0.747	+0.116	.001	.006	3	5
LIVER	FAM83H →	-2.405	-0.250	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007623 vs EXOSC9 — STOMACH

Explore this scatter interactively →