Rhythmic behavior

Across TCGA cell cohorts, RNA activity of the Rhythmic behavior pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN1A, ZMAT3, and SESN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN1A grouped by Rhythmic behavior-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CDKN1A →	-2.468	-1.093	<.001	.001	3	5
SKIN	ZMAT3 →	-1.571	-1.573	<.001	<.001	3	5
SKIN	SESN1 →	-1.297	-1.191	<.001	<.001	3	5
BLOOD_Myeloma	MED29 →	+0.683	+1.681	.003	<.001	3	5
OVARY	ERI3 →	+0.488	+1.120	<.001	.002	3	4
OVARY	WNK4 →	-1.330	-1.412	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN1A by Rhythmic behavior activity — SKIN

Explore this box plot interactively →