Copulation

Across TCGA patient cohorts, RNA activity of the Copulation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FILIP1L, TMOD2, and AKAP12_S483, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Copulation activity versus FILIP1L in BRCA (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FILIP1L →	+0.425	+0.036	<.001	.001	3	6
BRCA	TMOD2 →	+0.449	+0.044	<.001	<.001	3	6
LSCC	AKAP12_S483 →	+0.714	+0.042	<.001	.001	3	6
COAD	AKAP12 →	+0.595	+0.038	<.001	<.001	3	6
BRCA	MAGED2_S247 →	-1.123	-0.044	<.001	<.001	3	6
BRCA	NID2 →	+0.424	+0.049	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007620 vs FILIP1L — BRCA

Explore this scatter interactively →