Copulation

Across TCGA patient cohorts, RNA activity of the Copulation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDHD, AQP1, and HLA-K, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Copulation activity versus LDHD in GBM (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LDHD →	+0.444	+0.353	.003	.008	3	4
GBM	AQP1 →	+1.587	+0.523	.001	<.001	3	4
BRCA	HLA-K →	+0.665	+0.148	.004	.004	3	4
GBM	SYNGR1 →	+0.919	+0.425	<.001	<.001	3	3
GBM	HTR2A →	+0.934	+0.296	<.001	.003	3	3
GBM	PEBP4 →	+0.634	+0.349	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007620 vs LDHD — GBM

Explore this scatter interactively →