Mating behavior

Across TCGA patient cohorts, RNA activity of the Mating behavior pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTYH2, ADAM23, and PCDH17, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mating behavior activity versus TTYH2 in GBM (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TTYH2 →	+0.631	+0.235	<.001	<.001	3	5
CCRCC	ADAM23 →	+0.630	+0.161	<.001	<.001	3	4
GBM	PCDH17 →	+0.699	+0.201	<.001	.004	3	4
BRCA	PPP1R1B →	+1.413	+0.169	.002	<.001	3	4
GBM	DTX1 →	+1.063	+0.277	<.001	<.001	3	4
BRCA	QKI →	+0.568	+0.144	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007617 vs TTYH2 — GBM

Explore this scatter interactively →