Mating behavior

Across TCGA cell cohorts, RNA activity of the Mating behavior pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are REEP2, KMT2A, and N6AMT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, REEP2 grouped by Mating behavior-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	REEP2 →	-1.544	-0.820	.002	.004	3	4
LUNG_NSCLC_LUAD	KMT2A →	-0.622	-0.681	.007	.002	3	3
LARGE_INTESTINE	N6AMT1 →	-0.573	-0.334	<.001	<.001	3	3
BONE	SREK1 →	-0.805	-1.805	.007	<.001	3	3
BONE	FOXK1 →	-0.843	-1.221	<.001	.002	3	3
CNS	SMAD5 →	-0.412	-0.778	.005	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

REEP2 by Mating behavior activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →