Mating behavior

Across TCGA cell cohorts, RNA activity of the Mating behavior pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PBX3, SNX10, and ENSA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mating behavior activity versus PBX3 in STOMACH (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PBX3 →	-2.908	-1.461	.003	.001	3	4
LUNG_NSCLC_LUSC	SNX10 →	-1.529	-1.642	.003	<.001	3	3
SOFT_TISSUE	ENSA →	-0.316	-1.742	.007	<.001	3	3
LARGE_INTESTINE	UXS1 →	+0.684	+1.045	.001	.004	3	3
LARGE_INTESTINE	CEP170 →	+0.966	+0.974	.005	.001	3	3
BREAST	TLCD3A →	-1.530	-1.224	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007617 vs PBX3 — STOMACH

Explore this scatter interactively →