Long-term memory

Across TCGA patient cohorts, RNA activity of the Long-term memory pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSD11B1, FAS, and RIPOR3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-term memory activity versus HSD11B1 in PDAC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HSD11B1 →	+0.615	+0.388	<.001	.007	2	6
LUAD	FAS →	+0.504	+0.574	.001	.003	3	5
BRCA	RIPOR3 →	+0.807	+0.758	<.001	.001	3	5
LSCC	RIPOR2 →	+1.033	+0.604	<.001	<.001	3	5
LUAD	MEF2C →	+0.579	+0.909	<.001	<.001	3	5
LSCC	FCGR2B →	+0.820	+0.536	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007616 vs HSD11B1 — PDAC

Explore this scatter interactively →