Short-term memory

Across TCGA patient cohorts, RNA activity of the Short-term memory pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COPZ2, NNMT, and RAB31, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Short-term memory activity versus COPZ2 in GBM (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COPZ2 →	+0.660	+0.110	<.001	.001	3	7
OV	NNMT →	+1.419	+0.124	<.001	<.001	3	6
OV	RAB31 →	+0.735	+0.117	<.001	<.001	3	6
LSCC	HCFC1 →	-0.186	-0.097	<.001	.002	3	6
UCEC	NELFA →	-0.184	-0.143	<.001	<.001	3	6
UCEC	COPB1 →	+0.136	+0.119	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007614 vs COPZ2 — GBM

Explore this scatter interactively →