Memory

Across TCGA patient cohorts, RNA activity of the Memory pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, PODN, and SRPX, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Memory activity versus CNRIP1 in BRCA (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNRIP1 →	+1.059	+0.380	<.001	.008	3	8
HNSC	PODN →	+0.886	+0.766	<.001	<.001	3	8
HNSC	SRPX →	+0.746	+0.601	.001	.001	3	7
BRCA	KCNE4 →	+2.078	+0.424	<.001	.002	3	7
BRCA	THY1 →	+1.178	+0.385	<.001	.002	3	7
BRCA	MAP1A →	+1.258	+0.485	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007613 vs CNRIP1 — BRCA

Explore this scatter interactively →