Memory

Across TCGA cell cohorts, RNA activity of the Memory pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPSM3, NLRC5, and KRT80, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Memory activity versus GPSM3 in BONE (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GPSM3 →	+2.702	+0.351	.007	.001	3	4
PANCREAS	NLRC5 →	+1.555	+0.258	.001	<.001	3	4
LARGE_INTESTINE	KRT80 →	+3.280	+0.300	<.001	<.001	3	4
OVARY	DCBLD2 →	+1.872	+0.170	.004	.006	3	4
BREAST	SIM2 →	+1.457	+0.191	<.001	<.001	3	4
STOMACH	PLPBP →	-0.945	-0.378	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007613 vs GPSM3 — BONE

Explore this scatter interactively →