Learning

Across TCGA patient cohorts, RNA activity of the Learning pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KLC2_S151, MAPRE3, and PVR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Learning activity versus KLC2_S151 in GBM (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KLC2_S151 →	+0.551	+0.037	<.001	<.001	3	5
GBM	MAPRE3 →	+0.356	+0.037	<.001	<.001	3	5
LUAD	PVR →	+0.396	+0.027	.001	.001	3	5
LUAD	RPS8_T130 →	+0.785	+0.046	<.001	<.001	3	4
LUAD	ACOT7 →	+0.401	+0.026	<.001	.003	3	4
COAD	TGFB1I1 →	-0.400	-0.018	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007612 vs KLC2_S151 — GBM

Explore this scatter interactively →