"Phototransduction, visible light"

Across TCGA patient cohorts, RNA activity of the "Phototransduction, visible light" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ENTPD1, TBC1D2B, and BNC2_S403, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Phototransduction, visible light" activity versus ENTPD1 in LSCC (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ENTPD1 →	-0.380	-0.053	.003	.009	3	6
GBM	TBC1D2B →	-0.214	-0.036	.002	.004	3	5
GBM	BNC2_S403 →	-0.848	-0.078	.001	<.001	3	5
PDAC	SSH1 →	-0.259	-0.074	<.001	<.001	3	5
PDAC	CD163 →	-0.320	-0.050	<.001	<.001	3	5
PDAC	COLEC12 →	-0.679	-0.065	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007603 vs ENTPD1 — LSCC

Explore this scatter interactively →