"Phototransduction, visible light"

Across TCGA patient cohorts, RNA activity of the "Phototransduction, visible light" pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NMT2, LPIN1, and KRT18P11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Phototransduction, visible light" activity versus NMT2 in GBM (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NMT2 →	+0.566	+0.233	<.001	<.001	3	4
PDAC	LPIN1 →	+0.335	+0.154	.007	.005	3	4
BRCA	KRT18P11 →	+0.580	+0.201	.008	<.001	3	4
PDAC	PBLD →	+0.646	+0.183	.001	.003	3	3
GBM	GBE1 →	-0.571	-0.179	.002	.001	3	3
GBM	TREM1 →	-1.357	-0.242	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007603 vs NMT2 — GBM

Explore this scatter interactively →