"Phototransduction, visible light"

Across TCGA patient cohorts, RNA activity of the "Phototransduction, visible light" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NMT2, CNTLN, and PTPN1_S352, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Phototransduction, visible light" activity versus NMT2 in GBM (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NMT2 →	+0.310	+0.193	<.001	<.001	3	4
PDAC	CNTLN →	-0.869	-0.283	<.001	<.001	3	3
GBM	PTPN1_S352 →	-0.329	-0.251	<.001	<.001	3	3
PDAC	RTN1_S352 →	+1.501	+0.254	<.001	<.001	3	3
UCEC	SMYD5_T391 →	-0.967	-0.398	.001	<.001	3	3
OV	CA3_S50 →	+2.173	+0.376	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007603 vs NMT2 — GBM

Explore this scatter interactively →