"Phototransduction, visible light"

Across TCGA cell cohorts, RNA activity of the "Phototransduction, visible light" pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HASPIN, SNX13, and KIF9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HASPIN grouped by "Phototransduction, visible light"-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HASPIN →	+0.642	+1.001	.001	.001	3	4
SOFT_TISSUE	SNX13 →	-1.098	-1.445	.001	.005	2	5
KIDNEY	KIF9 →	-0.682	-1.229	.005	.001	3	4
SOFT_TISSUE	MROH1 →	-1.450	-1.339	.004	.004	3	4
LARGE_INTESTINE	RPL4 →	+0.450	+0.994	.001	<.001	3	4
LARGE_INTESTINE	MRPL30 →	+0.439	+1.035	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HASPIN by "Phototransduction, visible light" activity — LARGE_INTESTINE

Explore this box plot interactively →