"Phototransduction, visible light"

Across TCGA cell cohorts, RNA activity of the "Phototransduction, visible light" pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Salubrinal, HG6-64-1, and ABT737, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Salubrinal grouped by "Phototransduction, visible light"-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Salubrinal →	+0.279	+1.964	.016	.026	1	1
LUNG_SCLC	HG6-64-1 →	+0.759	+1.964	.012	.026	1	1
LUNG_SCLC	ABT737 →	+0.750	+1.964	.010	.026	1	1
LUNG_SCLC	P22077 →	-0.929	-1.964	.043	.026	1	1
LUNG_SCLC	Pilaralisib →	+0.604	+1.964	.005	.026	1	1
LUNG_SCLC	Flavopiridol →	+0.424	+1.964	.020	.026	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Salubrinal by "Phototransduction, visible light" activity — LUNG_SCLC

Explore this box plot interactively →