Phototransduction

Across TCGA patient cohorts, RNA activity of the Phototransduction pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DCN, AVL9, and CAVIN3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phototransduction activity versus DCN in OV (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DCN →	-0.646	-0.035	<.001	.001	3	8
LUAD	AVL9 →	+0.367	+0.043	<.001	<.001	3	7
OV	CAVIN3 →	-0.616	-0.040	<.001	<.001	3	7
OV	EHD2 →	-0.624	-0.031	<.001	.003	3	7
LSCC	KANK2 →	-0.335	-0.049	<.001	<.001	3	7
OV	FERMT2 →	-0.427	-0.042	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007602 vs DCN — OV

Explore this scatter interactively →