Phototransduction

Across TCGA patient cohorts, RNA activity of the Phototransduction pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDS1, KRT18P11, and VAMP8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phototransduction activity versus CDS1 in HNSC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CDS1 →	+0.821	+0.340	<.001	.002	3	5
BRCA	KRT18P11 →	+0.735	+0.247	.006	<.001	3	4
BRCA	VAMP8 →	+0.461	+0.298	<.001	.003	3	3
BRCA	MXD4 →	+0.620	+0.215	.001	<.001	3	3
BRCA	DGKQ →	+0.615	+0.331	.001	.001	3	3
BRCA	SPNS3 →	+0.351	+0.204	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007602 vs CDS1 — HNSC

Explore this scatter interactively →