Phototransduction

Across TCGA cell cohorts, RNA activity of the Phototransduction pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA5A, SLC2A1, and STXBP5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phototransduction activity versus SEMA5A in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SEMA5A →	+1.194	+1.436	.002	<.001	3	4
LUNG_NSCLC_LUAD	SLC2A1 →	+1.185	+0.900	.005	.003	3	4
KIDNEY	STXBP5 →	+0.849	+1.234	.006	.008	3	4
LUNG_NSCLC_LUAD	PAM16 →	-0.470	-0.760	.006	.002	3	4
PANCREAS	TRHDE →	-1.655	-1.380	.005	.001	2	5
KIDNEY	YIPF2 →	+1.038	+1.245	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007602 vs SEMA5A — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →